Coronary disease & ACSCohort study
Prevalence and Prognostic Implications of Atherosclerotic Coronary Artery Disease in Type 2 Myocardial Infarction
- Observational U.S. cohort study
Authors' conclusion
CAD is common among patients with T2MI and myocardial injury and is associated with poor long-term outcomes. Its presence may facilitate risk-stratification and represent a potential therapeutic target.
Study context
- Population
- Emergency department patients undergoing high-sensitivity cardiac troponin T measurementT1MI 64 (7.5%) · T2MI 91 (11%) · myocardial injury 703 (82%)
- Participants
- 858 patients
- Exposure
- patients with T2MI or myocardial injury and coronary artery disease (CAD) vs type 1 myocardial infarction (MI)
- T2MI and CADn = 31
- myocardial injury and CADn = 245
- T1MIn = 64reference
Main finding
Major adverse cardiovascular outcomes · Two-year
Adjusted hazard ratio
1.95
95% CI 1.2–3.6
By group
T2MI and CAD vs T1MI
aHR 1.95 (95% CI 1.2–3.6)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | T2MI and CAD | myocardial injury and CAD | T1MI | aHR (95% CI) | |
|---|---|---|---|---|---|
| All-cause death · Two-year | 52% | Not reported in the abstract | 20% | 2.2 (1.0–4.5) | |
| Noncardiovascular death · Two-year | 26% | Not reported in the abstract | 5% | 5.04 (1.3–19.3) | |
| Acute MI · Two-year | 13% | Not reported in the abstract | 2% | 9.2 (1.01–84.2) | |
| Heart failure hospitalization · Two-year | 32% | Not reported in the abstract | 8% | 4.6 (1.6–13.7) | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Outcomes in myocardial injury and CAD vs T1MI · Two-year
- similar trends, although differences were not statistically significant after adjustment
Original publication
Prevalence and Prognostic Implications of Atherosclerotic Coronary Artery Disease in Type 2 Myocardial Infarction. JACC Adv. Published 19 March 2026. doi:10.1016/j.jacadv.2026.102688
Summarised from the published abstract; every number is checked against it