Valvular & structural heart diseaseMeta-analysis
Prevalence and prognostic role of untreated moderate-to-severe tricuspid regurgitation: a systematic review and meta-analysis
- Systematic review and meta-analysis
- random-effects models
- PubMed searched from inception to 14 August 2025
Authors' conclusion
Untreated moderate-to-severe TR is associated with higher risk of all-cause mortality, CV mortality and HF hospitalization
Study context
- Population
- Patients with untreated tricuspid regurgitation (TR) of different grades
- Participants
- 961,136 patients · 106 studies
- Comparison
- Untreated moderate-to-severe TR vs none-to-mild TR
- Outcome
- All-cause mortality
Pooled result
As reported in the abstract
Hazard ratio
2.07
95% CI 1.89–2.26
P < 0.001
Moderate-to-severe TR vs None-to-mild TR
HR 2.07 (95% CI 1.89–2.26); P < 0.001
Further pooled results
| Outcome | HR (CI) | |
|---|---|---|
| CV mortality | 1.92 (1.64–2.26) | |
| HF hospitalization | 1.63 (1.44–1.84) | |
| 0.512Hazard ratio (log scale) |
Prevalence of untreated moderate-to-severe TR
- Overall prevalence, varied widely across subgroups
- 13.5%
Original publication
Prevalence and prognostic role of untreated moderate-to-severe tricuspid regurgitation: a systematic review and meta-analysis. Eur J Heart Fail. Published 6 June 2026. doi:10.1093/ejhf/xuag192
Summarised from the published abstract; every number is checked against it