Heart failure & cardiomyopathiesCohort study
Prevalence and Prognostic Significance of Restriction Versus Systolic Dysfunction in Patients With Transthyretin and Light Chain Cardiac Amyloidosis
- retrospectively analyzed
- real-world cohort
- assessed at the time of diagnosis
Authors' conclusion
Restriction was the most common presenting phenotype, while preserved LV function represented approximately one-third. The rate of progression from preserved LV function towards restriction was high, whereas it was limited towards systolic dysfunction. Although patients with preserved LV function presented the best event-free survival, considering all-cause mortality and heart transplantation, compared with restriction or systolic dysfunction, these phenotypes are not independent predictors of this composite end point.
Study context
- Population
- Patients with transthyretin (TTR) and light chain (AL) cardiac amyloidosis (CA)TTR-CA 540 · AL-CA 280
- Exposure
- Left ventricular (LV) systolic dysfunction versus restriction
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Freedom from the composite end point of all-cause mortality and heart transplantation, TTR-CA · 3-year
Prevalence of LV phenotypes, AL-CA · at the time of diagnosis
Freedom from the composite end point of all-cause mortality and heart transplantation, AL-CA · 3-year
Conversion rate among patients with preserved LV function, TTR-CA · at the last evaluation
- to restriction
- 16.3%
- to systolic dysfunction
- 1.8%
Conversion rate among patients with preserved LV function, AL-CA · at the last evaluation
- to restriction
- 12.9%
- to systolic dysfunction
- none
Original publication
Summarised from the published abstract; every number is checked against it