Coronary disease & ACSCohort study
Prevalence, Characteristics, and Prognostic Relevance of Donor-Transmitted Coronary Artery Disease in Heart Transplant Recipients
- Retrospective cohort study
- multicentre
- 11 Spanish centres
Authors' conclusion
TCAD was not associated with reduced survival in patients alive and well enough to undergo post-HT angiography within the first 3 months; however, s-TCAD patients showed increased risk of cardiovascular death and MACE.
Study context
- Population
- Consecutive adults undergoing heart transplantation in 11 Spanish centres, 2008–2018, with coronary angiography within 3 months after heart transplantation (HT)cohort of 1,918
- Participants
- 937 adults
- Exposure
- Donor-transmitted CAD vs no TCAD
- Significant TCAD (s-TCAD)n = 65
- Nonsignificant TCAD (ns-TCAD)n = 107
- Outcome
- Prevalence of TCAD and its prognostic relevance (clinical outcomes)
- Follow-up
- Median 6.3 years after c-angio
Main finding
As reported in the abstract
TCAD prevalence
- Any TCAD: 172 patients
- 18.3%
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality · multivariable Cox regression | 1.44 (0.89–2.35) | P = 0.141 | |
| CV mortality | 2.25 (1.20–4.19) | P = 0.011 | |
| CV death or nonfatal MACE | 2.42 (1.52–3.85) | P < 0.001 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
ns-TCAD and clinical outcomes
- No statistically significant impact of ns-TCAD on clinical outcomes
- Results similar with competing risks regression
Original publication
Prevalence, Characteristics, and Prognostic Relevance of Donor-Transmitted Coronary Artery Disease in Heart Transplant Recipients. J Am Coll Cardiol. Published 29 August 2023. doi:10.1016/j.jacc.2023.06.016
Summarised from the published abstract; every number is checked against it