Cohort study
Prevalence, Clinical Characteristics and Outcomes of Heart Failure Patients with or Without Isolated or Combined Mitral and Tricuspid Regurgitation: An Analysis from the ESC-HFA Heart Failure Long-Term Registry
- Prospective registry cohort study
- multicentre
- observational
Authors' conclusion
In a large cohort of outpatients with HF, prevalence of isolated and combined MR and TR was relatively high. Isolated TR was driven by HFpEF and was burdened by an unexpectedly poor outcome.
Study context
- Population
- Outpatients with heart failure (HF) without aortic valve disease, ESC-HFA EORP HF Long-Term Registry
- Participants
- 11,298 outpatients
- Exposure
- Isolated mitral regurgitation (MR), isolated tricuspid regurgitation (TR) or combined MR/TR vs no MR/TR
- No MR/TRn = 7,541reference
- Isolated MRn = 1,931
- Isolated TRn = 616
- Combined MR/TRn = 1,210
- Outcome
- Prevalence, clinical characteristics and outcomes of isolated or combined MR and TR
- Follow-up
- 1-year follow-up
Main finding
As reported in the abstract
Prevalence
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Isolated MR and combined MR/TR, by HF phenotype — HF with mildly reduced ejection fraction vs HF with reduced ejection fraction · isolated MR | 0.69 (0.60–0.80) | |
| Isolated MR and combined MR/TR, by HF phenotype — HF with mildly reduced ejection fraction vs HF with reduced ejection fraction · combined MR/TR | 0.51 (0.41–0.62) | |
| Isolated MR and combined MR/TR, by HF phenotype — HFpEF vs HF with reduced ejection fraction · isolated MR | 0.42 (0.36–0.49) | |
| Isolated MR and combined MR/TR, by HF phenotype — HFpEF vs HF with reduced ejection fraction · combined MR/TR | 0.59 (0.50–0.70) | |
| Isolated MR and combined MR/TR, by HF phenotype — HFpEF vs HF with reduced ejection fraction · isolated TR | 1.94 (1.61–2.33) | |
| 0.20.5125Odds ratio (log scale) |
All-cause death, CV death, HF hospitalisation and combined outcomes · 1 year
- More frequent in combined MR/TR, isolated TR and isolated MR vs no MR/TR; highest incidence rates in isolated TR and combined MR/TR
Original publication
Prevalence, Clinical Characteristics and Outcomes of Heart Failure Patients with or Without Isolated or Combined Mitral and Tricuspid Regurgitation: An Analysis from the ESC-HFA Heart Failure Long-Term Registry. Eur J Heart Fail. Published 26 June 2023. doi:10.1002/ejhf.2929
Summarised from the published abstract; every number is checked against it