Prevalence of Diastolic Dysfunction in Adult Survivors of Childhood Cancer: A Report From SJLIFE Cohort
Authors' conclusion
The prevalence of isolated diastolic dysfunction is low among adults who received cardiotoxic therapies for childhood cancer. The inclusion of left ventricular global longitudinal strain significantly increased the identification of diastolic dysfunction.
Study context
- Population
- Adult survivors of childhood cancer (≥18 years, ≥10 years from diagnosis) exposed to cardiotoxic therapy, SJLIFE1,435 with follow-up echo
- Participants
- 3,342 survivors
- Outcome
- Prevalence and progression of diastolic dysfunction (2016 ASE/EACVI guidelines)
Methodological detailslongitudinal echocardiographic follow-up
- Longitudinal echocardiographic follow-up
Main finding
As reported in the abstract
Diastolic dysfunction
Proportion at Echo 1
15.2%
baseline; 95% CI 14.0%–16.4%
Proportion at Echo 2
15.7%
last follow-up; 95% CI 13.9%–17.7%
Observational data: associations, not effects.
Further findings
Diastolic dysfunction in survivors with preserved EF
- Echo 1
- 2.2%
- Echo 2
- 3.7%
Diastolic dysfunction with GLS assessment (cutpoint worse than −15.9%), preserved EF
- Baseline
- 9.2%
- Follow-up
- 9.0%
Original publication
Prevalence of Diastolic Dysfunction in Adult Survivors of Childhood Cancer: A Report From SJLIFE Cohort. JACC CardioOncol. Published 21 March 2023. doi:10.
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