Heart failure & cardiomyopathies
Prevalence of Heart Failure Phenotypes and Current Use of Therapies in Primary Care: Results from a Nationwide Study
Authors' conclusion
HFrEF is the most common phenotype of HF in primary care followed by recovered HFrEF and fundamental therapies are markedly underutilized.
Study context
- Population
- Patients with heart failure (HF) (ICPC-2 code K77) in primary care clinics in Denmarkecho data in 1042 (94%)
- Participants
- 1,111 patients
- Exposure
- HF with Reduced Ejection Fraction (HFrEF) vs Recovered HFrEF vs HFmrEF or HFpEF
- Outcome
- Prevalence of HF phenotypes and current use of HF therapies
Methodological detailsnationwide, 148 primary care clinics, HF diagnosis made in a specialized setting in 95%
- Nationwide
- 148 primary care clinics
- HF diagnosis made in a specialized setting in 95%
Main finding
As reported in the abstract
HF phenotype prevalence
Observational data: associations, not effects.
Further findings
| Outcome | HFmrEF or HFpEF | OR | P value |
|---|---|---|---|
| HF therapy prescription by phenotypeHFmrEF or HFpEF vs HFrEF or recovered HFrEF · point estimates across drug classes | 0.33 to 0.57 | all P-values < 0.05 | |
| ACEi, ARB or ARNI | 67% | ||
| Beta-blocker | 67% | ||
| MRA | 22% | ||
| SGLT2 inhibitor | 7.4% | ||
| Treatment in older vs young patients (HFrEF or recovered HFrEF), all drug classesPoint estimates across drug classes | 0.50 to 0.69 | all P-values < 0.05 |
- HF therapy prescription by phenotype: HFrEF or recovered HFrEF ACEi, angiotensin receptor blocker (ARB) or angiotensin receptor neprilysin inhibitor (ARNI) 86% · Beta-blocker 82% · mineralocorticoid receptor antagonist (MRA) 38% · SGLT2 inhibitor 12%
Follow-up setting
- Follow-up solely in primary care
- 64%
- Solely primary care follow-up generally treated less vs specialized care; differences generally small
- Setting available in 96%
Original publication
Prevalence of Heart Failure Phenotypes and Current Use of Therapies in Primary Care: Results from a Nationwide Study. ESC Heart Fail. Published 28 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →