Heart failure & cardiomyopathiesMeta-analysis
Prevalence of Pathogenic Variants in Cardiomyopathy-Associated Genes in Acute Myocarditis
- Systematic review and meta-analysis of observational studies
- PRISMA
- PubMed and Embase searched on March 4, 2023
Authors' conclusion
Genetic variants are present in a large proportion of patients with acute myocarditis. The prevalence of genetic variants and the genes involved vary according to age and clinical presentation.
Study context
- Population
- Patients with acute myocarditis
- Participants
- 586 patients · 8 studies
- Comparison
- Uncomplicated myocarditis vs Complicated myocarditis, adults vs Complicated myocarditis, children
- Outcome
- Prevalence of pathogenic or likely pathogenic (P/LP) variants in cardiomyopathy-associated genes
Pooled result
As reported in the abstract
Pooled prevalence of P/LP variants
Pooled prevalence of P/LP variants Uncomplicated myocarditis 4.2% (95% CI 1.8%–7.4%) · Complicated myocarditis, adults 21.9% (95% CI 14.3%–30.5%) · Complicated myocarditis, children 44.5% (95% CI 22.7%–67.4%)
I²
- P/LP variants in cardiomyopathy-associated genes reported (89 variants)
- 85 patients
Further pooled results
| Outcome | Uncomplicated myocarditis | Complicated myocarditis, adults | Complicated myocarditis, children |
|---|---|---|---|
| Gene type of P/LP variants | |||
| Desmosomal genes (predominant) | 64% | Not reported in the abstract | Not reported in the abstract |
| Sarcomeric genes | Not reported in the abstract | 58% | 71% |
Original publication
Prevalence of Pathogenic Variants in Cardiomyopathy-Associated Genes in Acute Myocarditis. JACC Heart Fail. Published 3 April 2024. doi:10.1016/j.jchf.2024.02.012
Summarised from the published abstract; every number is checked against it