Heart failure & cardiomyopathies
Prevalence and Prognostic Significance of Restriction Versus Systolic Dysfunction in Patients With Transthyretin and Light Chain Cardiac Amyloidosis
Authors' conclusion
Restriction was the most common presenting phenotype, while preserved LV function represented approximately one-third. The rate of progression from preserved LV function towards restriction was high, whereas it was limited towards systolic dysfunction. Although patients with preserved LV function presented the best event-free survival, considering all-cause mortality and heart transplantation, compared with restriction or systolic dysfunction, these phenotypes are not independent predictors of this composite end point.
Study context
- Population
- Patients with transthyretin (TTR) and light chain (AL) cardiac amyloidosis (CA)TTR-CA 540 · AL-CA 280
- Exposure
- Left ventricular (LV) systolic dysfunction versus restriction
Methodological detailsreal-world cohort, assessed at the time of diagnosis
- Real-world cohort
- Assessed at the time of diagnosis
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Freedom from the composite end point of all-cause mortality and heart transplantation, TTR-CA · 3-year
Prevalence of LV phenotypes, AL-CA · at the time of diagnosis
Freedom from the composite end point of all-cause mortality and heart transplantation, AL-CA · 3-year
Conversion rate among patients with preserved LV function, TTR-CA · at the last evaluation
- To restriction
- 16.3%
- To systolic dysfunction
- 1.8%
Conversion rate among patients with preserved LV function, AL-CA · at the last evaluation
- To restriction
- 12.9%
- To systolic dysfunction
- none
Original publication
Summarised from the published abstract; every number is checked against it