Cardio-oncology & otherRandomised controlled trial
Preventing Allogeneic Stem Cell Transplant–Related Cardiovascular Dysfunction: ALLO-Active Trial
- Randomised controlled trial
Authors' conclusion
Intervening during and after allo-SCT with a multicomponent activity program during and after allo-SCT is beneficial for preserving a patient's cardiorespiratory fitness and exercise cardiac function.
Study context
- Population
- Adults scheduled for allogeneic stem cell transplantation (allo-SCT)52 (84%) completed follow-up
- Participants
- Sixty-two adults
- Comparison
- Multicomponent activity program vs usual care
- Activityn = 30
- Usual care (UC)n = 32reference
- Primary endpoint
- Co-primary: cardiorespiratory fitness (peak oxygen uptake) and exercise cardiac function (CIpeak, SVIpeak by exercise CMR)
- Follow-up
- 12 weeks after discharge
Primary result
As reported in the abstract
| Group | Peak oxygen uptake change | CIpeak change | SVIpeak change |
|---|---|---|---|
| Activity | −0.9 mL‧kg-1‧min-1 (95% CI, −2.5 to 0.8) | 0.30 L‧min-1‧m-2 (95% CI, −0.34 to 0.41) | 0.6 mL.m-2 (95% CI, −1.3 to 2.5) |
| UC | −3.4 mL‧kg-1‧min-1 (95% CI, −4.9 to −1.8) | −0.68 L‧min-1‧m-2 (95% CI, −1.3 to −0.32) | −2.7 mL.m-2 (95% CI, −4.6 to −0.9) |
- Activity vs UC: P = 0.029 — peak oxygen uptake; interaction P
- Activity vs UC: P = 0.008 — CIpeak; interaction P
- Activity vs UC: P = 0.014 — SVIpeak; interaction P
Further findings
- Adherence to activity program
- 74% · median · IQR 41%–96%
Cardiac biomarkers (cTn-I, BNP) and echocardiographic indices (LVEF, global longitudinal strain)
- No treatment effects of activity
Original publication
Preventing Allogeneic Stem Cell Transplant–Related Cardiovascular Dysfunction: ALLO-Active Trial. Circulation. Published 4 November 2024. doi:10.1161/circulationaha.124.070709
Summarised from the published abstract; every number is checked against it