Heart failure & cardiomyopathiesRandomised controlled trial
Preventive Catheter Ablation for Ventricular Arrhythmias in Patients with End-Stage Heart Failure Referred for Heart Transplantation Evaluation: Rationale for and Design of the CASTLE-VT Trial
- Randomised controlled trial (rationale and design)
Study context
- Population
- Patients with end-stage heart failure (HF) related to ischaemic cardiomyopathy referred for heart transplantation evaluationplanned
- Participants
- 160 patients
- Comparison
- Prophylactic substrate-based catheter ablation of ventricular scar vs no ablation
- Primary endpoint
- Composite of:
- All-cause mortality
- Worsening of HF requiring prioritized transplantation
- Left ventricular assist device (LVAD) implantation
Original publication
Preventive Catheter Ablation for Ventricular Arrhythmias in Patients with End-Stage Heart Failure Referred for Heart Transplantation Evaluation: Rationale for and Design of the CASTLE-VT Trial. Eur J Heart Fail. Published 11 November 2024. doi:10.1002/ejhf.3512
Summarised from the published abstract; every number is checked against it