Valvular & structural heart disease
Population Prevalence of Valvular Heart Disease in the United States: The PREVUE-VALVE Study
Authors' conclusion
In this national in-home echocardiography study, VHD was common among older adults, with important age-related and valve-specific patterns.
Study context
- Population
- US adults 65–85 years who previously filled a prescription at CVS or Walgreens pharmacies
- Participants
- 3,000 adults
- Outcome
- Prevalence of ≥ moderate VHD, weighted to US population; co-primary: prevalence of clinically significant VHD (incl. mild-to-moderate regurgitant disease)
Methodological detailsdecentralized, in-home echocardiography, randomly selected national sample, weighted to US population
- Decentralized
- In-home echocardiography
- Randomly selected national sample
- Weighted to US population
Main finding
As reported in the abstract
Weighted prevalence of ≥ moderate valvular heart disease (VHD)
8.2%
95% CI 7.0%–9.5%
Weighted prevalence of clinically significant VHD (co-primary)
18.4%
95% CI 16.7%–20.2%
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted RR (95% CI) | |
|---|---|---|
| Any VHD by race/ethnicity (age- and sex-adjusted) | 0.91 (0.83–0.99) | |
| 0.512Adjusted relative risk (log scale) |
- Any VHD by race/ethnicity (age- and sex-adjusted): driven predominantly by lower rates of aortic stenosis and regurgitation
Any VHD by race/ethnicity (age- and sex-adjusted)
- No significant adjusted differences between Hispanic and non-Hispanic individuals
Lesion type and age/sex
- Tricuspid regurgitation most common lesion, followed by AS, mitral regurgitation, aortic regurgitation, mitral stenosis
- Older age, but not sex, associated with greater prevalence
Extrapolation to US population aged 65-85
- ≥ moderate VHD currently (at least)
- 4.7 million
- Clinically significant VHD currently
- 10.6 million
- Projected by 2060, ≥ moderate / clinically significant
- 6.5 and 14.7 million
Original publication
Population Prevalence of Valvular Heart Disease in the United States: The PREVUE-VALVE Study. J Am Coll Cardiol. Published 16 June 2026. doi:10.
Summarised from the published abstract; every number is checked against it