Heart failure & cardiomyopathiesCohort study
Primary Left Atrial Cardiopathy in Transthyretin Amyloidosis Cardiomyopathy by Multimodality Imaging
- Retrospective cohort study
- propensity-score matched
- registry
Authors' conclusion
Primary LA cardiopathy seems to be associated with TEs in ATTR-CM, independently of AF, CHA2DS2-VASc, and LA dilatation, unlike other LVH phenotypes.
Study context
- Population
- Subjects with speckle tracking echocardiography, Tc-99m pyrophosphate scintigraphy and immune electrophoresis per registry protocolmatched cohort 104:104
- Participants
- 405 subjects
- Exposure
- ATTR-CM vs nonamyloid left ventricular hypertrophy (LVH)
- ATTR-CMn = 149
- LVHn = 165reference
- Outcome
- LA remodeling and its association with thrombotic events
- Follow-up
- 5 years
Main finding
As reported in the abstract
LA remodeling, ATTR-CM vs LVH
- LASr associated with ATTR-CM, independent of diastolic dysfunction and atrial fibrillation (AF)
- OR 1.2; P < 0.001
- Left atrial (LA) stiffness associated with ATTR-CM, independent of diastolic dysfunction and AF
- OR 1.9; P = 0.002
- LASr and LA stiffness independently associated with thrombotic events in ATTR-CM, regardless of CHA2DS2-VASc or prevalent AF
- 20
Observational data: associations, not effects.
Further findings
LASr in ATTR-CM
- LASr correlated poorly with E/e', severely depressed regardless of diastolic dysfunction grade (sinus rhythm), no correlation with LA volume index, unlike LVH
Original publication
Primary Left Atrial Cardiopathy in Transthyretin Amyloidosis Cardiomyopathy by Multimodality Imaging. JACC Cardiovasc Imaging. Published 3 July 2025. doi:10.1016/j.jcmg.2025.04.007
Summarised from the published abstract; every number is checked against it