Heart failure & cardiomyopathies
Pro-Adrenomedullin Associates with Congestion in Acute Heart Failure Patients
Authors' conclusion
Elevated pro-adrenomedullin is associated with in-hospital worsening heart failure and with death during follow-up in patients with acute heart failure.
Study context
- Population
- Unselected patients presenting with acute HF
- Participants
- 233 patients
- Outcome
- Association of pro-adrenomedullin with congestion and clinical outcomes (in-hospital death, post-discharge mortality, in-hospital worsening HF per RELAX-AHF-2 criteria)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Association with congestion at enrolment, β (depending on score)
0.36 and 0.81
each P < 0.05
Association with congestion at discharge, β
1.12
P < 0.001
Enrolment pro-adrenomedullin and in-hospital worsening HF, OR
4.23 (1.87, 9.58), P < 0.001 (95% CI)
Discharge pro-adrenomedullin and post-discharge death, HR
3.93
1.86, 8.67P < 0.001
Observational data: associations, not effects.
Further findings
Clinical outcomes (cohort) · median follow-up 1.92 years (95% CI: 1.76, 2.46)
- Median pro-adrenomedullin, nmol/L (IQR)
- 2.0 (1.4, 2.9)
- In-hospital death
- 8 (3.5%)
- In-hospital worsening HF
- 100 (44.1%)
- Post-discharge death
- 60 (36.6%)
Original publication
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