Procedural and Clinical Outcomes After Orbital Atherectomy Versus Intravascular Lithotripsy in Patients With Calcified Nodules
Main finding · Target-lesion failureResult — go to the resultAdjusted hazard ratio 1.10 95% CI 0.28–4.31Authors' conclusion
In patients with OCT-defined CNs, OA- and IVL-assisted PCI resulted in comparable post-PCI minimal stent area and 2-year clinical outcomes.
Study context
- Population
- Patients with optical coherence tomography (OCT)-defined calcified nodules undergoing percutaneous coronary intervention (PCI) with pre- and post-PCI OCT, 2012–2022
- Participants
- 167 patients
- Exposure
- Orbital atherectomy (OA) vs intravascular lithotripsy (IVL)-facilitated PCI
- OAn = 83
- IVLn = 84reference
- Outcome
- Imaging end point: minimal stent area on final post-PCI OCT; clinical end point: target-lesion failure:
- Cardiac death
- Target-vessel MI
- Clinically driven target-lesion revascularization
- Follow-up
- 2 years
Methodological detailspropensity score matching (sensitivity analysis)
- Propensity score matching (sensitivity analysis)
Main finding
Target-lesion failure
Adjusted hazard ratio
1.10
95% CI 0.28–4.31
P = 0.89
By group
OA vs IVL
adjusted HR 1.10 (95% CI 0.28–4.31); P = 0.89
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Propensity score-matched population (n=68 per group)OA vs IVL · minimal stent area · matched cohort | P = 0.73 |
| Propensity score-matched population (n=68 per group)OA vs IVL · 2-year target-lesion failure · matched cohort | log-rank P=0.82 |
Original publication
Procedural and Clinical Outcomes After Orbital Atherectomy Versus Intravascular Lithotripsy in Patients With Calcified Nodules. Circ Cardiovasc Interv. Published 15 August 2025. doi:10.
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