Arrhythmias & electrophysiologyCohort study
Procedural and Intermediate-term Results of the Electroanatomical-guided Cardioneuroablation for the Treatment of Supra-Hisian Second- or Advanced-degree Atrioventricular Block: the PIRECNA multicentre registry
- Retrospective multicentre registry
- international
- 20 centres
Authors' conclusion
This is the largest multicentre study demonstrating the feasibility of EACNA with encouraging intermediate-term outcomes in selected patients with VAVB.
Study context
- Population
- Patients with symptomatic paroxysmal or persistent vagally induced AV block (VAVB)
- Participants
- 130 patients
- Outcome
- Syncope and daytime second- or advanced-degree AVB on serial prolonged ECG monitoring
- Follow-up
- During
Main finding
As reported in the abstract
Syncope or daytime second- or advanced-degree AVB on serial prolonged ECG monitoring · median follow-up 300 days (150, 496)
Primary outcome in cases with acute procedural success
17/125 (14%)
Recurrence of AVB
9
New syncope
8
Observational data: associations, not effects.
Further findings
Acute procedural success (acute reversal of AVB and complete abolition of atropine response)
- Acute procedural success
- 96.2%
Factors associated with primary outcome
- Operator experience and use of extracardiac vagal stimulation similar with and without primary outcome
- History of AF, hypertension and CAD associated with higher primary outcome occurrence
Pacemaker placement during follow-up
- Patients with primary outcome requiring pacemaker placement
- 4
Original publication
Procedural and Intermediate-term Results of the Electroanatomical-guided Cardioneuroablation for the Treatment of Supra-Hisian Second- or Advanced-degree Atrioventricular Block: the PIRECNA multicentre registry. Europace. Published 2 July 2024. doi:10.1093/europace/euae164
Summarised from the published abstract; every number is checked against it