Arrhythmias & electrophysiologySecondary analysis
Procedural characteristics and clinical outcomes from same-day discharge after pulsed field ablation treatment for atrial fibrillation: an admIRE trial sub-analysis
- Secondary analysis of the admIRE trial
Authors' conclusion
SDD is feasible in a paroxysmal AF population undergoing PFA with the VLCC, demonstrating comparable safety and effectiveness outcomes with overnight hospitalization.
Study context
- Population
- Patients with paroxysmal atrial fibrillation (AF) undergoing pulsed field ablation (PFA) with a variable-loop circular catheter (VLCC)
- Participants
- 277 patients
- Comparison
- Same-day discharge (SDD) vs overnight stays (ONS) after PFA
- SDDn = 119
- ONSn = 158reference
- Primary endpoint
- Freedom from composite failure:
- Primary effectiveness
- Kaplan-Meier
Primary result
As reported in the abstract
Freedom from primary effectiveness failure
Further findings
Baseline and procedural characteristics, SDD vs ONS
- Patients aged ≥65 years, SDD vs ONS
- 41.2% vs. 52.5%
- Fluoroscopy time, SDD vs ONS
- 4.0 vs. 8.9 min
- First-pass isolation rate, SDD vs ONS
- 97.5% vs. 82.9%
- Procedures in the morning, SDD vs ONS
- 63.0% vs. 39.2%
Safety
Post-procedural serious cardiac/vascular AEs · comparable
Procedural AEs
- Procedural AEs, SDD vs ONS
- 1.7% vs. 3.8%
Serious adverse events (≤7 days and ≥1 day post-index procedure)
- No significant difference in SAE risk overall, SDD vs ONS: HR
- 1.07 (95% CI 0.47-2.44)
- No significant difference in SAE risk ≤7 days post-procedure, SDD vs ONS: HR
- 0.78 (95% CI 0.17-3.49)
Original publication
Procedural characteristics and clinical outcomes from same-day discharge after pulsed field ablation treatment for atrial fibrillation: an admIRE trial sub-analysis. Europace. Published 15 November 2025. doi:10.1093/europace/euaf270
Summarised from the published abstract; every number is checked against it