Heart failure & cardiomyopathies

Prognosis of patients in end-stage heart failure with atrial fibrillation treated with ablation: Insights from CASTLE-HTx

Heart RhythmPublished Secondary analysis of the CASTLE-HTx randomised trial

Primary result · Primary end point by risk group, ablation vs medical therapyResult — go to the resultHazard ratio 4.98 95% CI 2.08–11.9

Authors' conclusion

The absolute benefit of ablation is more pronounced in high-risk patients, but low-risk patients may also benefit.

Study context

Population
Patients with end-stage heart failure (HF) and atrial fibrillation (AF)
Participants
194 patients
Comparison
AF ablation vs medical therapy, by CASTLE-HTx risk score
  • Low riskn = 89reference
  • High riskn = 105
Primary endpoint
Primary end point (components not defined in abstract)
Follow-up
Median 18 months

Primary result

As reported in the abstract

Primary end point by risk group, ablation vs medical therapy

Hazard ratio

4.98

95% CI 2.08–11.9

Events by treatment group

High-risk

31

events

Low-risk

6

events

High-riskvs Low-risk
HR 4.98 (95% CI 2.08–11.9)

Original publication

Prognosis of patients in end-stage heart failure with atrial fibrillation treated with ablation: Insights from CASTLE-HTx. Heart Rhythm. Published 9 April 2024. doi:10.1016/j.hrthm.2024.04.013

Composed by AI from the published abstract and checked against it. How Briefs are made →

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