Valvular & structural heart disease
Prognosis of tricuspid regurgitation after mitral transcatheter edge-to-edge repair: the EXPANDed studies
- pooled cohort from the EXPAND and EXPAND G4 studies
- echo core lab
+1 more
- echo core lab
Authors' conclusion
Early TR improvement to ≤moderate was observed in almost 3/4 of the population and was associated with significant symptomatic relief. Patients with both severe MR and TR, particularly those with LV dilation, may experience TR improvement following MTEER.
Study context
- Population
- Patients with severe tricuspid regurgitation (TR) who achieved procedural success with mitral transcatheter edge-to-edge repair (MTEER) with the MitraClip System and received no direct TR interventionevaluable TR data at 30 days
- Participants
- 160 patients
- Exposure
- 30-day TR severity following MTEER: ≤moderate TR vs ≥severe TR
- ≤moderate TRn = 116
- ≥severe TRn = 44
Main finding
As reported in the abstract
TR severity at 30 days · 30 days
Observational data: associations, not effects.
Further findings
Baseline atrial fibrillation
Baseline LV ejection fraction
One-year mortality
Baseline LVEDV
| Outcome | ≤moderate TR | ≥severe TR |
|---|---|---|
| TR at 1 year | TR reduction sustained 86% | improved to ≤moderate 45% |
- Baseline atrial fibrillation: P = .009
- Baseline LV ejection fraction: P = .07
- Baseline LVEDV: P = .01
- One-year mortality: HR = 1.92 [.77, 4.79], P = .16 (not statistically significant)
NYHA functional class and KCCQ-OS score (≤moderate TR group) · through 1 year
- NYHA functional class improvement P
- P < 0.0001
- KCCQ-OS score Δ
- + 30.6 ± 25.7, P < .0001
Associations with TR improvement post-MTEER
- Lower LVEF and larger baseline LV size were associated with TR improvement
Original publication
Prognosis of tricuspid regurgitation after mitral transcatheter edge-to-edge repair: the EXPANDed studies. ESC Heart Fail. Published 16 April 2026. doi:10.1093/eschf/xvag108
Summarised from the published abstract; every number is checked against it