Valvular & structural heart disease
Prognostic impact of cardiac damage staging classification in each aortic stenosis subtype undergoing transcatheter aortic valve implantation (TAVI)
Authors' conclusion
Cardiac damage staging classifications stratified mortality after TAVI irrespective of AS subtype.
Study context
- Population
- Patients with severe aortic stenosis (AS) undergoing TAVI: High-gradient AS (HG-AS), classical low-flow (LF) low-gradient AS (LG-AS), LF LG-AS with preserved ejection fraction (pEF), normal-flow (NF) LG-ASHG-AS 1,045 · classical LF LG-AS 337 · LF LG-AS with pEF 394 · NF LG-AS 314
- Participants
- 2,090 patients
- Exposure
- Advanced vs early cardiac damage, by AS subtype
- Outcome
- Mortality
- Follow-up
- 5 years
Main finding
As reported in the abstract
Mortality after TAVI, advanced vs early cardiac damage, by AS subtype
Advanced stage vs Early stageAdjusted hazard ratio (95% CI)
HG-AS
1.66(1.34–2.06)
Classical LF LG-AS
1.49(1.02–2.16)
LF LG-AS with pEF
1.69(1.22–2.35)
NF LG-AS
1.52(1.04–2.32)
Observational data: associations, not effects.
Further findings
Prevalence of advanced cardiac damage, by AS subtype
Original publication
Prognostic impact of cardiac damage staging classification in each aortic stenosis subtype undergoing TAVI. EuroIntervention. Published 4 December 2023. doi:10.
Summarised from the published abstract; every number is checked against it