Coronary disease & ACSResearch article
Prognostic impact of combined inflammatory markers in patients undergoing percutaneous coronary intervention
- Consecutive patients undergoing percutaneous coronary intervention (PCI) between 2012 and 2022
- Multivariable Cox proportional hazards models
Authors' conclusion
In patients undergoing PCI, elevated NLR identifies a gradient of increasing risk, particularly when combined with hs-CRP ≥2 mg/L. A dual-marker inflammatory approach may improve post-PCI risk stratification beyond either biomarker alone.
Study context
- Population
- Consecutive patients undergoing PCI between 2012 and 2022
- Participants
- 7,303 included patients
- Comparison
- Elevated neutrophil-to-lymphocyte ratio (NLR) vs NLR below the 75th percentile, within high-sensitivity C-reactive protein (hs-CRP) strata
- Outcome
- Major adverse cardiovascular events (MACE)
- Follow-up
- 1 year
Main finding
As reported in the abstract
Elevated NLR vs NLR <75th percentileHazard ratio (95% CI)P value
hs-CRP ≥2 mg/L
1.83(1.42–2.35)
P < 0.001hs-CRP <2 mg/L
1.55(1.10–2.17)
P = 0.012Original publication
Prognostic impact of combined inflammatory markers in patients undergoing percutaneous coronary intervention. Am Heart J. Published 21 June 2026. doi:10.1016/j.ahj.2026.107519
Summarised from the published abstract; every number is checked against it