Prognostic impact of guideline-directed medical therapy after functionally complete revascularisation in patients with obstructive coronary artery diseases
Authors' conclusion
In patients who achieved FCR, the benefit of good adherence to GDMT remained significant, starting from the second year and continuing up to 3 years.
Study context
- Population
- Patients with obstructive coronary artery disease who achieved functionally complete revascularisation (functional complete revascularisation (FCR)) in the FAVOR III China trialpatients who achieved FCR (85.2%)
- Participants
- 3,221 patients
- Comparison
- Guideline-directed medical therapy (GDMT) vs non-GDMT groups
- Primary endpoint
- MACCE:
- Death
- Myocardial infarction
- Stroke
- Ischaemia-driven revascularisation
- Follow-up
- 3 years
Primary result
As reported in the abstract
GDMT group vs non-GDMT groupAdjusted hazard ratio (95% CI)P value
From the second year
0.66(0.51–0.85)
P < 0.01Sustained until the third year
0.65(0.50–0.85)
P < 0.01- Major adverse cardiac and cerebrovascular events (MACCE) through 3 years, all FCR patients
- 313 (10.2%)
Further findings
Adherence to GDMT · 1 month, 6 months, 1 year, 2 years and 3 years
- 1 month
- 1964 (61.2%)
- 6 months
- 1919 (59.9%)
- 1 year
- 1545 (48.4%)
- 2 years
- 1483 (46.6%)
- 3 years
- 1084 (35.3%)
Original publication
Prognostic impact of guideline-directed medical therapy after functionally complete revascularisation in patients with obstructive coronary artery diseases. Heart. Published 7 August 2025. doi:10.
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