Prognostic impact of hypercoagulability and impaired fibrinolysis in acute myocardial infarction
Authors' conclusion
AMI occurrence is significantly associated with hypercoagulability and impaired fibrinolysis. Their combined phenotype increases the risk of post-PCI atherothrombotic event only in AMI patients.
Study context
- Population
- Consecutive patients undergoing percutaneous coronary intervention (PCI) with thrombogenicity indices measured by thromboelastography
- Participants
- 2,705 patients
- Exposure
- Acute myocardial infarction (AMI) vs non-AMI
- Outcome
- MACE:
- CV death
- Non-fatal MI
- Non-fatal stroke
- Follow-up
- Up to 4 years
Methodological detailsconsecutive patients, single-centre registry
- Consecutive patients
- Single-centre registry
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)P value
AMI vs Non-AMIcombined phenotypevs without, AMI
1.744(1.135–2.679)
P = 0.011Non-AMIcombined phenotypevs without, non-AMI
1.031(0.499–2.129)
P = 0.935Observational data: associations, not effects.
Further findings
Platelet-fibrin clot strength (MA)
P < 0.001
Fibrinolytic activity (LY30)
P < 0.001
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Association of index AMI presentation with MA and LY30AMI · per 1-mm increase in MA | 1.024 (1.013–1.036) | P < 0.001 | |
| Association of index AMI presentation with MA and LY30AMI · per 1% increase in LY30 | 0.934 (0.893–0.978) | P = 0.004 | |
| 0.512Odds ratio (log scale) |
Original publication
Prognostic impact of hypercoagulability and impaired fibrinolysis in acute myocardial infarction. Eur Heart J. Published 1 March 2023. doi:10.
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