Prognostic impact of neutrophil-to-lymphocyte ratio in patients with and without diabetes mellitus undergoing percutaneous coronary intervention
Authors' conclusion
Patients undergoing PCI with a higher NLR had worse clinical outcomes, regardless of DM status. The combination of DM and elevated NLR revealed the most unfavourable prognosis.
Study context
- Population
- Patients undergoing percutaneous coronary intervention (PCI) at a large tertiary centre between 2012 and 2022, stratified by presence of diabetes mellitus (DM)48.5% with DM
- Participants
- 9,427 patients
- Exposure
- Elevated neutrophil-to-lymphocyte ratio (NLR) vs lower NLR quartiles, in patients with and without DM
- Outcome
- MACE:
- All-cause mortality
- Spontaneous MI
- Stroke
Methodological detailssingle tertiary centre, multivariable Cox regression
- Single tertiary centre
- Multivariable Cox regression
Main finding
As reported in the abstract
DM, upper NLR quartile
15.7%
- DM patients in the upper NLR quartile had the highest rates of major adverse cardiovascular events (MACE) than any other subgroup
- 15.7%
Observational data: associations, not effects.
Secondary outcomes
Baseline characteristics
- DM patients had more comorbidities and higher baseline high-sensitivity C reactive protein levels
- Patients with elevated NLR in both subgroups exhibited multivessel disease with moderate/severe calcification
Original publication
Prognostic impact of neutrophil-to-lymphocyte ratio in patients with and without diabetes mellitus undergoing percutaneous coronary intervention. Heart. Published 21 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it