Heart failure & cardiomyopathies
Prognostic Impact of Peak Oxygen Consumption in Heart Failure: A Systematic Review and Meta-Analysis
Authors' conclusion
VO2peak is a prognostic marker for multiple causes of mortality and hospitalization in patients with HF
Study context
- Population
- Patients with heart failure (HF)64 studies
- Comparison
- Per 1 mL/kg/min increase in VO2peak
- Outcome
- Prognostic impact of VO2peak on adverse clinical outcomes (mortality)
Methodological detailsrandom-effects inverse-variance model, adjusted models, Search of PubMed, Scopus, Web of Science and Cochrane Library from inception until January 2025
- Random-effects inverse-variance model
- Adjusted models
- Search of PubMed, Scopus, Web of Science and Cochrane Library from inception until January 2025
Pooled result
As reported in the abstract
Mortality outcomes per 1 mL/kg/min increase in VO2peak
VO2peakHazard ratio (95% CI)P value
All-cause mortality; I2 = 85%
0.86(0.82–0.90)
P < 0.01VAD, transplant and all-cause mortality; I2 = 33%
0.84(0.79–0.89)
P < 0.01CV mortality; I2 = 0%
0.92(0.82–1.02)
P = 0.12Per 1 mL/kg/min increase in VO2peak, as printed
Further pooled results
Heterogeneity and publication bias
- Variance among studies by age, sex, BMI, LVEF, AF, hypertension, CKD, diabetes and treatment
- Significant risk of publication bias
Original publication
Prognostic Impact of Peak Oxygen Consumption in Heart Failure: A Systematic Review and Meta-Analysis. ESC Heart Fail. Published 12 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →