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Coronary disease & ACSCohort study

Prognostic Impact of Renal Function on Outcomes After Physiology-Guided Coronary Revascularization: Insights From the J-PRIDE Registry

Circ Cardiovasc IntervPublished

  • subanalysis of the J-PRIDE registry, a prospective multicenter study
  • 20 Japanese centers
Read the original article ↗

Authors' conclusion

Patients with ESRD exhibited distinct physiological characteristics and substantially worse outcomes, highlighting the need for tailored coronary revascularization strategies in this population.

Study context

Population
Patients who underwent both fractional flow reserve (FFR) and NHPR assessment, categorized by estimated glomerular filtration rate, Japan, September 2019 to February 2021patients, 4296 lesions · non-CKD 1,639 · chronic kidney disease (CKD) 1,321 · end-stage renal disease (ESRD) 234
Participants
3,194 patients
Exposure
ESRD group vs CKD and non-CKD groups
  • non-CKDn = 1,639reference
  • CKDn = 1,321reference
  • ESRDn = 234
Outcome
Target vessel failure:
  • Composite of cardiac death
  • Target vessel myocardial infarction
  • Clinically driven target vessel revascularization
Follow-up
1 year

Main finding

As reported in the abstract

Adjusted hazard ratio (95% CI)P value
ESRD vs CKD
3.09(1.60–5.96)
P < 0.001
ESRD vs non-CKD
2.88(1.98–5.47)
P = 0.001

Observational data: associations, not effects.

Further findings

FFR-/NHPR+ discordance

Outcomenon-CKDCKDESRD
NHPR cutoff predicting FFR ≤0.800.890.890.85
  • FFR-/NHPR+ discordance: P <0.001

Overall prevalence of FFR/NHPR discordance

Comparable across groups (23.6%, 19.7%, and 19.7%)
P = 0.24

Risk of FFR-/NHPR+ lesions in the ESRD group

FFR-/NHPR+ lesions in the ESRD group exhibited an excess risk compared with other lesions

Revascularization of FFR+/NHPR- lesions

Revascularization was beneficial in non-CKD patients with FFR+/NHPR- lesions, whereas no clear benefit was observed in patients with CKD and ESRD

Original publication

Prognostic Impact of Renal Function on Outcomes After Physiology-Guided Coronary Revascularization: Insights From the J-PRIDE Registry. Circ Cardiovasc Interv. Published 27 April 2026. doi:10.1161/circinterventions.125.016454
Read the original article ↗PubMedCite RIS · BibTeX

Summarised from the published abstract; every number is checked against it