Arrhythmias & electrophysiology
Prognostic Impact of Sinus Rhythm in Atrial Fibrillation Patients: Separating Rhythm Outcomes From Randomized Strategy Findings From the CABANA Trial
Primary resultResult — go to the resultAdjusted hazard ratio 0.57 95% CI 0.38–0.85Authors' conclusion
In patients in the CABANA trial with detailed long-term rhythm follow-up, increased time in SR was associated with a clinically consequential decrease in mortality and other adverse prognostic events.
Study context
- Population
- Atrial fibrillation (AF) patients in CABANA (ablation vs drug therapy) monitored with the CABANA ECG rhythm monitoring systemof 2204 randomised
- Participants
- 1,240 patients
- Comparison
- Sinus rhythm (SR) vs non-SR
- Primary endpoint
- Primary CABANA end point:
- Death
- Disabling stroke
- Serious bleeding
- Cardiac arrest
Methodological detailsprespecified analysis, time-dependent Cox model, stratified by randomised treatment
- Prespecified analysis
- Time-dependent Cox model
- Stratified by randomised treatment
Primary result
As reported in the abstract
Adjusted hazard ratio
0.57
95% CI 0.38–0.85
P = 0.006
SRvs Non-SR
adjusted HR 0.57 (95% CI 0.38–0.85); P = 0.006
Further findings
Primary end point by AF documented during follow-up
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality | 0.59 (0.35–1.01) | P = 0.053 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- Primary end point by AF documented during follow-up: documented AF n=883; no AF n=357
Documented AF during postblanking follow-up
- Any documented AF
- 883 (71.2%)
- AF within first year (of 883)
- 671 (76.0%)
- First AF after ≥1 year (of 883)
- 212 (24.0%)
Original publication
Prognostic Impact of Sinus Rhythm in Atrial Fibrillation Patients: Separating Rhythm Outcomes From Randomized Strategy Findings From the CABANA Trial. Circ Arrhythm Electrophysiol. Published 17 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →