Prognostic impact of quantitative flow ratio (QFR)-consistent complete revascularization in patients with myocardial infarction and multivessel coronary artery disease
Primary resultResult — go to the resultHazard ratio 0.17 95% CI 0.10–0.30Authors' conclusion
Among patients with myocardial infarction and multivessel disease, a QFR-consistent complete revascularization was associated with a reduced risk of all-cause mortality, nonfatal myocardial infarction, and ischemia-driven revascularization.
Study context
- Population
- Patients with MI and multivessel CAD
- Participants
- 792 patients1,320 nonculprit vessels
- Comparison
- QFR-consistent PCI vs QFR-inconsistent PCI
- QFR-consistent PCIn = 646
- QFR-inconsistent PCIn = 146reference
- Primary endpoint
- Composite of:
- All-cause death
- Nonculprit vessel-related nonfatal MI
- Ischemia-driven revascularization
- Follow-up
- 2 years after index MI
Methodological detailscohort study, post-hoc QFR analysis, blinded outcome assessment of QFR
- Cohort study
- Post-hoc QFR analysis
- Blinded outcome assessment of QFR
Primary result
As reported in the abstract
Hazard ratio
0.17
95% CI 0.10–0.30
P < 0.001
Events by treatment group
QFR-consistent PCIvs QFR-inconsistent PCI
HR 0.17 (95% CI 0.10–0.30); P < 0.001
Further findings
| Outcome | QFR-consistent PCI | QFR-inconsistent PCI | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Nonfatal MI | 2.0% | 15.1% | 0.13 (0.06–0.25) | P < 0.001 | |
| Ischemia-driven revascularization | 1.2% | 5.5% | 0.21 (0.08–0.57) | P = 0.001 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Prognostic impact of quantitative flow ratio (QFR)-consistent complete revascularization in patients with myocardial infarction and multivessel coronary artery disease. Am Heart J. Published 20 July 2024. doi:10.
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