Heart failure & cardiomyopathies
Prognostic Implications of Genotype Findings in Non-Ischaemic Dilated Cardiomyopathy: A Network Meta-Analysis
Authors' conclusion
Different genetic substrates associated with DCM result in divergent natural histories.
Study context
- Population
- Patients with non-ischaemic dilated cardiomyopathy (DCM)
- Participants
- 7,255 patients · 26 studies
- Comparison
- Genotype groups vs genotype-negative or other genotypes
- Outcome
- Composite adverse events (CAEs), malignant ventricular arrhythmic events (MVAEs) and HF events (HFEs)
Pooled result
As reported in the abstract
Each group vs genotype-negativeOdds ratio (95% CI)
P/LPCAEs
2.10(1.67–2.65)
P/LPMVAEs
1.86(1.52–2.26)
P/LPHFEs
2.01(1.08–3.73)
TTNtvCAEs
1.78(1.20–2.63)
Original publication
Prognostic Implications of Genotype Findings in Non-Ischaemic Dilated Cardiomyopathy: A Network Meta-Analysis. Eur J Heart Fail. Published 30 July 2024. doi:10.
Summarised from the published abstract; every number is checked against it