Prognostic Implications of Preoperative hs-cTnT in Elective Coronary Artery Bypass Grafting
Authors' conclusion
Preoperative hs-cTnT is an independent predictor of adverse outcomes in elective CABG.
Study context
- Population
- Patients undergoing elective coronary artery bypass grafting (CABG) at 2 tertiary centres, 2010–2023
- Participants
- 5,450 patients
- Exposure
- Preoperative hs-cTnT categories: mildly or significantly elevated vs nonelevated
- Outcome
- Perioperative outcomes, 30-day mortality and 5-year mortality
Methodological detailspropensity score weighting, 2 tertiary centres, consecutive series
- Propensity score weighting
- 2 tertiary centres
- Consecutive series
Main finding
As reported in the abstract
Each group vs nonelevatedHazard ratio (95% CI)P value
Significantly elevated5-year mortality
1.55(1.28–1.86)
P < 0.001Significantly elevatedECMO use
2.96(1.81–4.84)
P < 0.001Mildly elevatedECMO use
1.65(1.01–2.69)
P = 0.046Significantly elevatedhemofiltration
2.99(2.27–3.94)
P < 0.001Mildly elevatedhemofiltration
2.25(1.75–2.90)
P < 0.001- Mildly elevated · 5-year mortality
- HR 1.37 (95% CI 1.14–1.34); P < 0.001
Observational data: associations, not effects.
Further findings
Prevalence of elevated preoperative hs-cTnT
- hs-cTnT >1x URL
- 26.6%
- hs-cTnT >3x URL
- 12.4%
Original publication
Prognostic Implications of Preoperative hs-cTnT in Elective Coronary Artery Bypass Grafting. JACC Adv. Published 23 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it