Acute cardiac care & resuscitationSecondary analysis
Prognostic performance of cardiogenic shock 4 proteins prediction model in infarct-related cardiogenic shock
- post-hoc analysis of the randomized CULPRIT-SHOCK trial
Authors' conclusion
The CS4P score provides acceptable short-term mortality risk stratification among patients with CS due to acute myocardial infarction. The CS4P prediction model exhibits superior prognostication among CS patients with STEMI as compared to NSTEMI and in STEMI patients without CPR prior to hospital presentation.
Study context
- Population
- Patients with cardiogenic shock (CS) presenting with ST-segment elevation myocardial infarction (STEMI) vs non-ST-segment elevation myocardial infarction (NSTEMI), with and without cardiopulmonary resuscitation (CPR)patients with CS included in this study · STEMI 240 · NSTEMI 172
- Participants
- 412 patients
- Comparison
- STEMI vs NSTEMI
- STEMIn = 240
- NSTEMIn = 172
- Primary endpoint
- Composite of:
- Mortality
- Necessity for renal replacement therapy
- Follow-up
- 30-day follow-up
Primary result
As reported in the abstract
STEMI
0.74
AUC · 95% CI 0.67–0.80
NSTEMI
0.69
AUC · 95% CI 0.61–0.77
P = 0.05
Further findings
| Outcome | Values | hazard ratio (95% CI) | P value | |
|---|---|---|---|---|
| Mortality · within 30 days · higher mortality in highest tertile | 1.42 (1.11–1.82) | P = 0.005 | ||
| 0.512Hazard ratio (log scale) |
| Outcome | Values | Estimate | P value |
|---|---|---|---|
| Prognostic performance of CS4P score in STEMI by prior CPR · higher prognostic performance without CPR | STEMI patients who had not undergone CPR prior to enrolment AUC 0.78 (95% CI 0.65–0.84) · STEMI patients with preceding CPR AUC 0.70 (95% CI 0.62–0.79) | P < 0.001 |
Original publication
Prognostic performance of cardiogenic shock 4 proteins prediction model in infarct-related cardiogenic shock. ESC Heart Fail. Published 20 January 2026. doi:10.1093/eschf/xvag010
Summarised from the published abstract; every number is checked against it