Acute cardiac care & resuscitationCohort study
Prognostic performance of plasma and urinary biomarkers of kidney injury and function after out-of-hospital cardiac arrest
- prospective observational study
Authors' conclusion
Kidney-specific biomarkers were superior to sCr for early AKI detection and prediction of patient-centered outcomes after OHCA. Early biomarker measurement may improve AKI and outcome risk stratification beyond conventional sCr-based assessment.
Study context
- Population
- Comatose adult OHCA patients
- Participants
- 82 patients
- Exposure
- Kidney injury biomarkers vs serum creatinine (sCr) for early prediction of patient-centered outcomes and acute kidney injury (AKI) after OHCA
- sCr rose by >20% and/or required dialysisn = 33
- decreasing by >20%n = 23
- stable sCrn = 7
- Outcome
- Poor neurological recovery or mortality (CPC 3-5)
- Follow-up
- Hospital discharge
Main finding
As reported in the abstract
- Cerebral Performance Category (CPC) 3-5
- 45 (54.9%)
- died, CPC 5
- 39
- poor neurological recovery, CPC 3-4
- 6
- Urinary neutrophil gelatinase-associated lipocalin (NGAL) AUC for CPC 3-5
- 0.79
- sCr AUC for CPC 3-5
- 0.57
Observational data: associations, not effects.
Secondary outcomes
| Outcome | sCr rose by >20% and/or required dialysis | decreasing by >20% | stable sCr |
|---|---|---|---|
| CPC 3-5 incidence by sCr trajectory | 71% | Not reported in the abstract | Not reported in the abstract |
- CPC 3-5 incidence by sCr trajectory: decreasing by >20% or stable sCr 20%
- CPC 3-5 incidence by sCr trajectory: p < 0.001
CPC 3-5 incidence by sCr trajectory
- Elevated biomarkers in patients with rising sCr and/or dialysis
AKI (secondary outcome)
- AKI occurred
- 54 (65.9%)
- of whom required renal replacement therapy
- 19 (23.2%)
- Urinary NGAL AUC for AKI
- 0.81
- Admission kidney biomarkers AUCs for AKI
- 0.75-0.85
- sCr AUC for AKI
- 0.65
Original publication
Prognostic performance of plasma and urinary biomarkers of kidney injury and function after out-of-hospital cardiac arrest. Resuscitation. Published 8 June 2026. doi:10.1016/j.resuscitation.2026.111163
Summarised from the published abstract; every number is checked against it