Congenital heart diseaseCohort study
Prognostic Performance of Right Ventricular Global Longitudinal Strain Measurements in Patients With Ebstein Anomaly
- Cohort study
Authors' conclusion
These data support the use of RVGLS for risk stratification in Ebstein anomaly
Study context
- Population
- Adults with Ebstein anomaly with echocardiographic assessment of right ventricular (RV) systolic function, 2003–2020
- Participants
- 620 adults
- Outcome
- All-cause mortality by absolute RVGLS
Main finding
All-cause mortality
Adjusted hazard ratio
0.94
95% CI 0.92–0.96
Absolute RVGLS
adjusted HR 0.94 (95% CI 0.92–0.96)
Per unit increase, as printed
As reported in the abstract
- Deaths during follow-up
- 47 (8%)
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | |
|---|---|---|
| CV mortality · per unit increase | 0.92 (0.90–0.94) | |
| 0.512Adjusted hazard ratio (log scale) |
- CV mortality — CV deaths
- 34
Prognostic power vs RVFAC, RV s', TAPSE
- Absolute RVGLS had superior prognostic power vs RVFAC, RV s' or TAPSE
Correlation of absolute RVGLS with conventional indices
- RVGLS vs RVFAC
- r = 0.71; P < 0.001
- RVGLS vs RV s'
- r = 0.41; P = 0.03
- RVGLS vs TAPSE
- r = 0.44; P = 0.002
RV systolic function indices (whole cohort)
- Absolute RVGLS, mean
- 18% ± 5%
- RVFAC, mean
- 32% ± 9%
- RV s', mean
- 14 ± 6 cm/s
- TAPSE, mean
- 22 ± 8 mm
Original publication
Prognostic Performance of Right Ventricular Global Longitudinal Strain Measurements in Patients With Ebstein Anomaly. J Am Coll Cardiol. Published 8 August 2023. doi:10.1016/j.jacc.2023.05.045
Summarised from the published abstract; every number is checked against it