Heart failure & cardiomyopathiesCohort study
Prognostic Role of Myocarditis-Like Episodes and Their Treatment in Patients With Pathogenic Desmoplakin Variants
- Observational cohort study
- multicentre
Authors' conclusion
Immunosuppressive treatment of myocarditis-like episodes in DSP patients was associated with improved combined ventricular arrhythmia or heart failure outcomes
Study context
- Population
- Patients with pathogenic or likely pathogenic desmoplakin (DSP) variants in the DSP-ERADOS Network, 31 institutions177 with myocarditis-like episode
- Participants
- 1,014 patients
- Exposure
- Immunosuppressive treatment vs No immunosuppressive treatment
- Immunosuppressive treatmentn = 63
- Outcome
- Ventricular arrhythmia and HF end points
- Follow-up
- Median 6.4 years
Main finding
As reported in the abstract
Immunosuppressive treatment vs No immunosuppressive treatmentHazard ratio (95% CI)P value
ventricular arrhythmia
0.18(0.07–0.45)
P < 0.001HF
0.09(0.02–0.39)
P = 0.001Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Recurrent myocarditis-like episodes after completion of initial immunosuppression | 0.85 (0.47–1.54) | P = 0.599 | |
| 0.512Hazard ratio (log scale) |
NSAIDs or colchicine treatment
- Nonsteroidal anti-inflammatory drugs or colchicine did not influence outcomes
Original publication
Prognostic Role of Myocarditis-Like Episodes and Their Treatment in Patients With Pathogenic Desmoplakin Variants. Circulation. Published 20 August 2025. doi:10.1161/circulationaha.125.073919
Summarised from the published abstract; every number is checked against it