Prognostic significance of beat-to-beat variability of spatial heterogeneity of repolarization analyzed from a 5-minute resting electrocardiogram in coronary artery disease
Authors' conclusion
TMD-SD is independently associated with the long-term risk of SCD/SCA in patients with CAD.
Study context
- Population
- Patients with angiographically verified coronary artery disease (CAD) and well-preserved LV function, 5-minute resting 12-lead ECG before clinical stress test
- Participants
- 1,702 patients
- Exposure
- TMD-SD in patients with vs without SCD/SCA, nonsudden cardiac death (NSCD) or noncardiac death
- SCD/SCAn = 60
- NSCDn = 69
- Noncardiac deathn = 161
- Outcome
- Prognostic value of beat-to-beat variability of T-wave morphology (TMD-SD) for SCD/SCA, NSCD and noncardiac death
- Follow-up
- Average 8.7 ± 2.2 years
Main finding
As reported in the abstract
TMD-SD
Hazard ratio (95% CI)P value
TMD-SDrisk of SCD/SCA, Cox multivariable model
1.119(1.015–1.233)
P = 0.024TMD-SDrisk of NSCD, Cox multivariable model
1.089(0.983–1.206)
P = 0.103- SCD/SCA vs other patients
- mean ± SD 1.72 ± 2.00 vs 1.12 ± 1.75; P = 0.01
- NSCD vs other patients
- mean ± SD 1.57 ± 1.74 vs 1.12 ± 1.76; P = 0.04
- Noncardiac death vs no such event
- mean ± SD 1.16 ± 1.42 vs 1.14 ± 1.79; P = 0.86
Observational data: associations, not effects.
Original publication
Prognostic significance of beat-to-beat variability of spatial heterogeneity of repolarization analyzed from a 5-minute resting electrocardiogram in coronary artery disease. Heart Rhythm. Published 10 April 2024. doi:10.
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