Valvular & structural heart diseaseCohort study
Prognostic significance of aortic valve calcification in relation to coronary artery calcification for cardiovascular diseases
- Prospective cohort study
Authors' conclusion
Our results indicated a synergistic interaction between valve calcification and coronary calcification in CVDs.
Study context
- Population
- Participants of the Multi-Ethnic Study of Atherosclerosis at baseline (mean age 62.2 ± 10.2 years, 47.2% male)
- Participants
- 6,695 participants
- Exposure
- Aortic valve calcification (AVC) and/or coronary artery calcification (CAC) vs neither
- Outcome
- CVD
Main finding
As reported in the abstract
Hazard ratio
3.43
CI 2.69–4.37
P < 0.001
Both AVC and CAC vs No AVC or CAC
HR 3.43 (CI 2.69–4.37); P < 0.001
- Additive interaction between AVC and CAC significant
- P < 0.001
Observational data: associations, not effects.
Further findings
All-cause death
- Same trend for all-cause death and in subgroup analyses
- 1274 cases (19.0%) of all-cause death overall
Predictive value of pooled cohort equations (PCEs)
- Predictive value of PCEs increased when AVC and CAC were added
Original publication
Prognostic significance of aortic valve calcification in relation to coronary artery calcification for cardiovascular diseases. Eur J Prev Cardiol. Published 23 February 2024. doi:10.1093/eurjpc/zwae078
Summarised from the published abstract; every number is checked against it