Valvular & structural heart diseaseCohort study
Prognostic significance of concomitant valvular disease in moderate aortic regurgitation
- retrospectively analyzed
- dedicated echocardiographic database
Authors' conclusion
Moderate AR with another concomitant moderate VHD carries a prognosis similar to significant AR, indicating this combination is not benign and may be underestimated by current guidelines.
Study context
- Population
- Patients with ≥ moderate aortic regurgitation (AR) (2017–2023) without cardiomyopathy, prior cardiac surgery, LVEF <50%, or severe valvular heart disease (VHD) other than ARpatients with ≥ moderate AR
- Participants
- 794 patients
- Exposure
- moderate AR plus ≥ one concomitant moderate VHD and isolated significant AR vs isolated moderate AR
- isolated moderate ARn = 178
- isolated significant ARn = 214
- moderate AR plus ≥ one concomitant moderate VHDn = 402
Main finding
As reported in the abstract
Composite endpoint of:
- All-cause mortality
- Heart failure hospitalization (HHF)
Hazard ratio (95% CI)P value
Moderate AR with another VHDindependently predicted higher risk
2.83(1.32–6.03)
P = 0.007isolated significant AR
2.65(1.23–5.70)
P = 0.013- patients who met the composite endpoint
- 151 patients (18.8%)
- HHF
- 63
- deaths
- 108
Observational data: associations, not effects.
Further findings
Age
- Patients with moderate AR plus another VHD were older
- 79.9 vs. 66.4 years, P < 0.001
- more comorbidities and larger left atria
Original publication
Prognostic significance of concomitant valvular disease in moderate aortic regurgitation. Eur Heart J Cardiovasc Imaging. Published 12 February 2026. doi:10.1093/ehjci/jeag045
Summarised from the published abstract; every number is checked against it