Valvular & structural heart disease
Prognostic significance of mitral annular calcification assessed by computed tomography for transcatheter edge-to-edge repair outcomes
Authors' conclusion
Overall, all-cause mortality did not significantly differ between patients with varied MAC severity. However, greater calcium thickness and leaflet involvement were associated with worse clinical outcomes in patients undergoing TEER. Detailed preoperative CT evaluation can facilitate the prediction and management of TEER outcomes.
Study context
- Population
- Patients who underwent transcatheter edge-to-edge repair (TEER) and preprocedural computed tomography (CT)patients who underwent pre-TEER cardiac CT
- Participants
- 391 patients
- Exposure
- no/mild mitral annular calcification (MAC) vs moderate/severe MAC
- no/mild MACn = 318
- moderate/severe MACn = 73
- Outcome
- All-cause mortality
- Follow-up
- 3 years after TEER
Main finding
As reported in the abstract
P = 0.17
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| New York Heart Association Class · 3 years · significantly better with no/mild MAC | P = 0.029 |
Predictors of all-cause mortality at 3 years
- Calcium thickness >5 mm, OR 2.38
- P = 0.032 (95% CI 1.08-5.25)
- Leaflet involvement, OR 6.71
- P < 0.001 (95% CI 3.28-13.7)
- Both indicators: significantly higher incidence of all-cause mortality compared to those with calcium thickness ≤5 mm and no leaflet calcification
Original publication
Prognostic significance of mitral annular calcification assessed by computed tomography for transcatheter edge-to-edge repair outcomes. EuroIntervention. Published 4 August 2025. doi:10.
Summarised from the published abstract; every number is checked against it