Heart failure & cardiomyopathies
Prognostic Significance of Plasma Chloride in Elderly Patients Hospitalized for Acute Heart Failure
Authors' conclusion
In very old patients hospitalized with AHF, plasma chloride was associated with the risk of death and HF readmission in a U-shaped pattern and could potentially be used for congestion phenotyping.
Study context
- Population
- Very old patients hospitalised for acute heart failure (HF) (median age 85 years, 62% women, 80% HFpEF)
- Participants
- 429 patients
- Exposure
- Hypochloraemia phenotypes vs normochloraemia
- Outcome
- Time to all-cause mortality and composite of death and/or HF readmission
Main finding
As reported in the abstract
All-cause mortality
Hazard ratio
1.86
P = 0.008
Depletional
Hazard ratio
0.94
P = 0.855
Dilutional
Observational data: associations, not effects.
Original publication
Prognostic Significance of Plasma Chloride in Elderly Patients Hospitalized for Acute Heart Failure. ESC Heart Fail. Published 22 June 2023. doi:10.
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