Heart failure & cardiomyopathiesCohort study
Prognostic Significance of Unintentional Weight Loss in Heart Failure with Preserved Ejection Fraction
- Retrospective cohort study
Authors' conclusion
Unintentional weight loss is associated with worse prognosis in patients with HFpEF and overweight or obesity, even as haemodynamics, exercise capacity, and gas exchange are not different from patients with stable or increasing weight.
Study context
- Population
- Overweight or obese patients with invasively proven HFpEF, without weight-reducing therapies or known malignancy, undergoing invasive haemodynamic cardiopulmonary testing
- Participants
- 434 participants
- Exposure
- Tertile 1 vs tertiles 2 or 3 of annualized weight change
Main finding
As reported in the abstract
All-cause death; all-cause death or heart failure (HF) hospitalization; cardiac death or HF hospitalization · median follow-up 4.7 years (IQR 2.3-6.5)
Tertile 1 vs Tertile 2 or 3Hazard ratio (95% CI)P value
all-cause death
3.36(1.77–6.39)
P < 0.001all-cause death or HF hospitalization
2.49(1.53–4.04)
P < 0.001cardiac death or HF hospitalization
2.28(1.28–4.07)
P = 0.005Observational data: associations, not effects.
Further findings
Baseline haemodynamics and metabolic parameters
- Baseline weight correlated with right and left heart filling pressures
- r = 0.23-0.34, p < 0.001
- Annualized weight change not correlated with any baseline haemodynamic measurement
- all p > 0.05
- Tertile 1 had subtle abnormalities in ventilatory control at baseline; no other significant differences between groups at rest or exercise
Original publication
Prognostic Significance of Unintentional Weight Loss in Heart Failure with Preserved Ejection Fraction. Eur J Heart Fail. Published 26 June 2025. doi:10.1002/ejhf.3745
Summarised from the published abstract; every number is checked against it