Aortic & peripheral vascular diseaseCohort study
Prognostic Utility of Perivascular Adipose Tissue Attenuation in Patients Undergoing Endovascular Aneurysm Repair for Abdominal Aortic Aneurysms
- retrospective study
- consecutive patients
Authors' conclusion
In patients undergoing EVAR, higher PVAT attenuation was associated with both MACCE and AAA-related adverse events. PVAT attenuation may provide incremental prognostic value for identifying patients at higher risk of unfavorable outcomes following EVAR.
Study context
- Population
- Patients who underwent endovascular aortic repair (EVAR) for unruptured infrarenal abdominal aortic aneurysm (AAA) with preprocedural computed tomography angiographypatients treated with EVAR
- Participants
- 275 patients
- Exposure
- higher perivascular adipose tissue (PVAT) attenuation
- patients who experienced MACCEn = 98
- Outcome
- MACCE, a composite of all-cause death, myocardial infarction, stroke, and any vessel treatment
- Follow-up
- Median 3.5 years
Main finding
As reported in the abstract
Unadjusted hazard ratio
1.88 per 10 HU
95% CI 1.56–2.28
P < 0.001
higher PVAT attenuation (per 10 HU)
unadjusted hazard ratio 1.88 per 10 HU (95% CI 1.56–2.28); P < 0.001
Per 10 HU, as printed
- experienced MACCE
- 35.6% (98/275)
Observational data: associations, not effects.
Further findings
| Outcome | unadjusted hazard ratio (per 10 HU) (95% CI) | P value | |
|---|---|---|---|
| AAA-related adverse events: a composite of AAA-related death, reintervention for AAA, embolization for endoleak, and AAA enlargement | 2.16 (1.59–2.94) | ||
| 0.20.5125Unadjusted hazard ratio (log scale) |
| Outcome | patients who experienced MACCE | those who did not | Estimate | P value |
|---|---|---|---|---|
| Pre-EVAR PVAT attenuation · higher in patients who experienced MACCE | −69.8 ± 10.3 HU | −77.3 ± 8.6 HU | P < 0.001 |
Predictive and reclassification abilities for MACCE after EVAR
- Adding PVAT attenuation to post-EVAR prognostic factors and computed tomography angiography findings improved the predictive and reclassification abilities
Original publication
Prognostic Utility of Perivascular Adipose Tissue Attenuation in Patients Undergoing Endovascular Aneurysm Repair for Abdominal Aortic Aneurysms. Circ Cardiovasc Imaging. Published 28 April 2026. doi:10.1161/circimaging.125.019185
Summarised from the published abstract; every number is checked against it