Coronary disease & ACSSecondary analysis
Prognostic value of AI-derived ventricular imaging phenotypes from cardiac computed tomography angiography (CTA) for long-term risk of myocardial infarction: analysis of SCOT-HEART trial
- Post hoc analysis
- within the Scottish Computed Tomography of the Heart (SCOT-HEART) trial
Authors' conclusion
Myocardial radiomic phenotypes based on CTA may offer incremental prognostic value for long-term MI prediction, beyond conventional established cardiovascular risk factors and imaging features.
Study context
- Population
- Participants of the SCOT-HEART trial who underwent cardiac CTAparticipants followed over a median of 8.6 years
- Participants
- 1,736 participants
- Comparison
- The prognostic model incorporating myocardial radiomic phenotypes was compared to clinical models based on cardiovascular risk factors, calcium score, and presence of obstructive disease
Primary result
As reported in the abstract
Fatal or non-fatal MI · median follow-up of 8.6 years
Participants with fatal or non-fatal myocardial infarction (MI)
82 of 1736 participants (4.7%)
Further findings
C-index
| Outcome | Clinical model with myocardial radiomic phenotypes | Clinical model | Δ C-index | P value |
|---|---|---|---|---|
| Discrimination and model fit for future MI events · improved discrimination (C-index from 0.693 to 0.722) | 0.722 | 0.693 | 0.029 | P < 0.001 |
- Discrimination and model fit for future MI events — Improved model fit (likelihood ratio test, χ2)
- 13.5, P = 0.009
Associations of myocardial radiomic phenotypes with age, sex, hypertension, and diabetes
- Myocardial radiomic phenotypes were associated with age, sex, hypertension, and diabetes
- P < 0.01 for all
- Older age, male sex, and cardiometabolic risk linked to increased myocardial volume and density
Myocardial radiomic features associated with MI (univariable analysis)
- Features associated with MI, among those associated with cardiovascular risk factors
- 22 features
Original publication
Prognostic value of AI-derived ventricular imaging phenotypes from cardiac CTA for long-term risk of myocardial infarction: analysis of SCOT-HEART trial. Eur Heart J Cardiovasc Imaging. Published 10 September 2026. doi:10.1093/ehjci/jeag252
Summarised from the published abstract; every number is checked against it