Heart failure & cardiomyopathiesCohort study
Prognostic value of cardiac magnetic resonance global T2 mapping in patients with takotsubo syndrome
- retrospective
- consecutive TTS patients
- imaging re-analysed, blinded to clinical data
Authors' conclusion
Global myocardial T2 may provide incremental prognostic information beyond prespecified clinical and imaging indices in TTS and refine risk stratification.
Study context
- Population
- Takotsubo syndrome (TTS) patients undergoing cardiac magnetic resonance (CMR) with tissue mapping within 30 days of admissionmedian age 68 years, 91% women
- Participants
- 110 participants
- Exposure
- Global myocardial T2 and MACE
- Outcome
- MACE:
- All-cause death
- Heart failure hospitalization
- Recurrent TTS
- Stroke
- Transient ischaemic attack
- Follow-up
- Median 763 days (IQR 525-1357)
Main finding
As reported in the abstract
each 5 ms increase in global T2Hazard ratio (95% CI)P value
ridge-penalized Cox models
1.40(1.06–1.87)
P = 0.020after adjustment in the Firth-penalized model
1.70(1.20–2.40)
P = 0.004Each 5 ms increase in global T2, as printed
- experienced MACE
- 17 (15.5%)
Observational data: associations, not effects.
Further findings
Global T2
- median global T2
- 56 ms (IQR 53-60)
T2 ≥ 63 ms for 1-year MACE
- AUC
- 0.671
- sensitivity
- 56%
- specificity
- 89%
- Kaplan-Meier curves separated
- log-rank P = 0.003
- internally derived threshold
- modest 1-year discrimination
Original publication
Prognostic value of cardiac magnetic resonance global T2 mapping in patients with takotsubo syndrome. Eur Heart J Cardiovasc Imaging. Published 7 September 2026. doi:10.1093/ehjci/jeag243
Summarised from the published abstract; every number is checked against it