Coronary disease & ACSDiagnostic or prognostic study
Prognostic Value of Coronary Angiography–Derived Index of Microcirculatory Resistance in Non–ST-Segment Elevation Myocardial Infarction Patients
- Prognostic cohort study
- multicentre (3 sites)
Authors' conclusion
In patients undergoing PCI for NSTEMI, an increased post-PCI angio-IMR is associated with a higher risk of MACEs. The addition of post-PCI angio-IMR into conventional risk factors significantly improves the ability to reclassify patients and estimate the risk of MACEs.
Study context
- Population
- Patients with NSTEMI undergoing postpercutaneous coronary intervention (PCI), culprit-vessel angio-IMR measured after PCI
- Participants
- 2,212 patients · 3 sites
- Comparison
- Post-PCI angio-IMR >25 vs ≤25
- angio-IMR >25n = 206
- Outcome
- MACE:
- Cardiac death
- Readmission for HF
- Myocardial reinfarction
- Target vessel revascularization
- Follow-up
- 2 years
Performance
MACE
Hazard ratio
4.230
95% CI 3.151–5.679
P < 0.001
By group
angio-IMR >25 vs angio-IMR ≤25
HR 4.230 (95% CI 3.151–5.679); P < 0.001
As reported in the abstract
Further findings
| Outcome | Values |
|---|---|
| Mean post-PCI angio-IMR | NSTEMI mean 20.63 (SD 4.17) |
Incremental prognostic value vs conventional risk factors
- AUC 0.774 vs 0.716
- P < 0.001
- Net reclassification index 0.317
- P < 0.001
- Integrated discrimination improvement 0.075
- P < 0.001
Original publication
Prognostic Value of Coronary Angiography–Derived Index of Microcirculatory Resistance in Non–ST-Segment Elevation Myocardial Infarction Patients. JACC Cardiovasc Interv. Published 7 August 2024. doi:10.1016/j.jcin.2024.04.048
Summarised from the published abstract; every number is checked against it