Coronary disease & ACSSecondary analysis
Prognostic Value of Coronary Angiography-Derived Index of Microcirculatory Resistance in Patients With Intermediate Coronary Stenosis
- Post hoc analysis of the FLAVOUR randomised trial
- Median follow-up 24.8 months (Q1-Q3: 24.4-26.4 months)
Authors' conclusion
In individuals with intermediate coronary stenosis, elevated angio-IMR is linked to an adverse prognosis.
Study context
- Population
- Patients with intermediate coronary stenosis (FLAVOUR trial)
- Participants
- 1,658 patients
- Comparison
- Angio-IMR >25 vs angio-IMR ≤25
- Primary endpoint
- Patient-oriented composite outcome (POCO):
- All-cause death
- MI
- Revascularization
- Follow-up
- 2 years
Primary result
As reported in the abstract
POCO
Angio-IMR >25
35.06% [27 of 77]
Percutaneous coronary intervention (PCI) · Non-PCI 17.95% [21 of 117]
Angio-IMR ≤25
7.2% [51 of 708]
PCI · Non-PCI 4.23% [32 of 756]
Angio-IMR >25 vs Angio-IMR ≤25Hazard ratio (95% CI)P value
PCI, adjusted
6.235(3.811–10.203)
P < 0.001non-PCI, adjusted
5.282(2.948–9.462)
P < 0.001Further findings
| Outcome | C-index | P value |
|---|---|---|
| Incremental prognostic value of adding angio-IMR — Angiographic model + angio-IMR vs Angiographic model | 0.710 vs 0.615 | P < 0.001 |
| Incremental prognostic value of adding angio-IMR — Clinical model + angio-IMR vs Clinical model | 0.705 vs 0.594 | P < 0.001 |
- Incremental prognostic value of adding angio-IMR: 95% CI 0.663-0.756 vs 0.563-0.664; NRI 0.268 (0.191-0.362); IDI 0.055 (0.030-0.108)
- Incremental prognostic value of adding angio-IMR: 95% CI 0.658-0.751 vs 0.544-0.644; NRI 0.268 (0.171-0.350); IDI 0.057 (0.027-0.102)
Original publication
Prognostic Value of Coronary Angiography-Derived Index of Microcirculatory Resistance in Patients With Intermediate Coronary Stenosis. JACC Cardiovasc Interv. Published 27 January 2025. doi:10.1016/j.jcin.2024.10.017
Summarised from the published abstract; every number is checked against it