Heart failure & cardiomyopathiesCohort study
Prognostic value of early changes in NT-proBNP across left ventricular ejection fraction status in acute heart failure
- Retrospective cohort study
- multicentre
- three tertiary centres
- consecutive patients
Authors' conclusion
Early NT-proBNP reduction is a robust prognostic marker in AHF with LVEF up to 64%. Its utility is limited in patients with supranormal LVEF.
Study context
- Population
- Consecutive patients hospitalized for acute HF at three tertiary centres
- Participants
- 3,276 patients
- Exposure
- Prognostic value of early ΔNT-proBNP across left ventricular ejection fraction (LVEF) categories
- Outcome
- All-cause mortality, CV death and recurrent HF hospitalizations
- Follow-up
- Median 1.65 years (0.40-2.66)
Main finding
As reported in the abstract
Association of ΔNT-proBNP with all outcomes, by LVEF category
Significant interaction between ΔNT-proBNP and LVEF category for all outcomes
P for interaction <.05
Observational data: associations, not effects.
Further findings
Distribution of LVEF categories
ΔNT-proBNP (admission to 48-72 hours)
- Median ΔNT-proBNP
- 8.8% (−38.7 to 22.9)
- Decline of ≥30%
- 32.3%
Events during follow-up · median follow-up 1.65 years (0.40-2.66)
- Deaths
- 1420 (43.4%)
- HF readmissions
- 1979
- Patients with HF readmissions
- 1045
Original publication
Prognostic value of early changes in NT-proBNP across left ventricular ejection fraction status in acute heart failure. Eur J Heart Fail. Published 21 January 2026. doi:10.1093/ejhf/xuag018
Summarised from the published abstract; every number is checked against it