Heart failure & cardiomyopathies
Prognostic Value of N-terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) in Patients Treated With Allogeneic Stem Cell Transplantation
Authors' conclusion
Baseline NT-proBNP in patients treated with alloSCT is positively associated with an increased risk of all-cause mortality. NT-proBNP ≥125 ng/L was associated with a significant lower 5-year survival.
Study context
- Population
- Patients referred for allogeneic stem cell transplantation 2012–2023 with NT-proBNP measured <180 days before transplantation
- Participants
- 807 patients
- Exposure
- Higher vs lower baseline NT-proBNP
- Outcome
- All-cause mortality
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
follow-up 1.6 (0.6-4.0) years
Hazard ratio (95% CI)P value
NT-proBNP ≥125 ng/Lvs NT-proBNP <125 ng/L
1.29(1.04–1.60)
P = 0.020Log-transformed NT-proBNP
1.21(1.11–1.31)
P < 0.001- Deaths during follow-up
- 393 (48.7%)
- Lower 5-year survival with NT-proBNP ≥125 ng/L
- P = 0.0035
Observational data: associations, not effects.
Further findings
Baseline NT-proBNP, died vs survived
P = 0.001
Original publication
Prognostic Value of NT-proBNP in Patients Treated With Allogeneic Stem Cell Transplantation. JACC Adv. Published 11 December 2025. doi:10.
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