Valvular & structural heart diseaseCohort study
Prognostic Value of NT-proBNP in Patients Undergoing Tricuspid Valve Transcatheter Edge-to-Edge Repair
- Registry-based cohort study
Authors' conclusion
Baseline NT-proBNP was independently associated with 2-year mortality or heart failure hospitalization after T-TEER.
Study context
- Population
- Patients undergoing tricuspid T-TEER with baseline NT-proBNP, EuroTR registry
- Participants
- 2,282 patients
- Exposure
- NT-proBNP tertiles
Main finding
All-cause mortality or first HF hospitalization · 2 years
Adjusted hazard ratio
1.62
95% CI 1.29–2.04
Baseline NT-proBNP vs Tertile 1
adjusted HR 1.62 (95% CI 1.29–2.04)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | adjusted OR per log10 increase (95% CI) | P value | |
|---|---|---|---|
| Symptomatic alleviation · lower likelihood of symptomatic alleviation | 0.63 (0.48–0.84) | P < 0.001 | |
| 0.512Adjusted or per log10 increase (log scale) |
Residual tricuspid regurgitation (TR) ≤2+ at discharge, by NT-proBNP tertile
- Residual TR ≤2+ at discharge across tertiles 1, 2 and 3: 86.3%, 82.9% and 81.4%
- P = 0.040
30-day NT-proBNP trajectory and primary endpoint
- Higher than expected 30-day NT-proBNP relative to baseline independently associated with higher subsequent risk of the primary endpoint
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prognostic Value of NT-proBNP in Patients Undergoing Tricuspid Valve Transcatheter Edge-to-Edge Repair. JACC Cardiovasc Interv. Published 3 March 2026. doi:10.1016/j.jcin.2026.02.013
Summarised from the published abstract; every number is checked against it