Valvular & structural heart diseaseCohort study
Prognostic Value of NT-ProBNP in Patients with Primary Mitral Regurgitation Undergoing Transcatheter Edge-To-Edge Repair
- Retrospective cohort study
- international
- multicentre registry (PRIME-MR)
Authors' conclusion
NT-proBNP, but not the MIDA score, was independently associated with death or heart failure hospitalizations within 3 years in M-TEER-treated PMR patients.
Study context
- Population
- Patients with primary mitral regurgitation undergoing mitral valve transcatheter edge-to-edge repair (M-TEER), with available NT-proBNP and follow-upof 3083 in registry
- Participants
- 1,382 patients
- Exposure
- NT-proBNP and MIDA score as predictors of outcome
- Outcome
- Death or HF hospitalization
- Follow-up
- 3 years
Main finding
As reported in the abstract
Adjusted hazard ratio
1.17
95% CI 1.07–1.28
P < 0.001
Log-transformed NT-proBNP
adjusted HR 1.17 (95% CI 1.07–1.28); P < 0.001
- Patients reaching primary endpoint
- 384
- Kaplan-Meier estimate
- 48.5%
- Median NT-proBNP (pg/ml)
- 1991
Observational data: associations, not effects.
Further findings
Modified MIDA score and death or HF hospitalization (n = 1041, median score 9) · 3 years
| Comparison | Estimate | P value | |
|---|---|---|---|
| MIDA score | HR 1.10 (95% CI 1.04–1.17) | P = 0.002 | |
| NT-proBNP · adjusted incl. MIDA score | adjusted HR 1.20 (95% CI 1.07–1.34) | P = 0.002 | |
| 0.512Ratio (log scale) |
- Modified MIDA score and death or HF hospitalization (n = 1041, median score 9): unadjusted for NT-proBNP; lost significance after adjusting for NT-proBNP
Original publication
Prognostic Value of NT-ProBNP in Patients with Primary Mitral Regurgitation Undergoing Transcatheter Edge-To-Edge Repair. Eur J Heart Fail. Published 18 June 2025. doi:10.1002/ejhf.3725
Summarised from the published abstract; every number is checked against it