Prevention & lipidsCohort study
Prognostic value of peripheral endothelial function on major adverse cardiovascular events above traditional risk factors
- Retrospective cohort study
Authors' conclusion
Peripheral microvascular dysfunction predicts cardiovascular events.
Study context
- Population
- Patients who underwent peripheral arterial tonometry, 2006–2020
- Participants
- 1,460 patients
- Exposure
- PMED vs no PMED
- Outcome
- MACE:
- MI
- HF hospitalization
- Cerebrovascular events
- All-cause mortality
Main finding
As reported in the abstract
MACE · median follow-up 7 years
- Risk of major adverse cardiovascular events (MACE) during follow-up
- 11.2%
- Lower reactive hyperaemia index (RHI) associated with worse MACE-free survival (Kaplan-Meier)
- P < 0.001
- Optimal RHI cut-off, overall
- 1.83
- Optimal RHI cut-off, females
- 1.61
- Optimal RHI cut-off, males
- 1.8
Observational data: associations, not effects.
Further findings
Optimal RHI cut-off for MACE
- Overall population
- 1.83
- Females
- 1.61
- Males
- 1.8
Original publication
Prognostic value of peripheral endothelial function on major adverse cardiovascular events above traditional risk factors. Eur J Prev Cardiol. Published 11 July 2023. doi:10.1093/eurjpc/zwad225
Summarised from the published abstract; every number is checked against it